|
»
Printer Friendly Version of Dynamic Axial Compression Columns
TechniKrom designs and manufactures 316L stainless steel (and
Hastelloy) LC columns ranging from 10cm to 2 meter internal
diameter and up to 2 meter length. We design, build and test
in accordance with ASME code calculations and FDA requirements
and provide IQ/OQ validation documentation.
Return To Top
TechniKrom now offers a complete line of chromatography columns,
dynamic axial compression or fixed. Our columns combine our
leading edge flow distribution system with patent-pending
hoist free design for ease of use. We offer bioprocess columns
from 5 cm to 2 meter i.d. and HPLC and MPLC columns from 5
cm to 1.4 meter i.d. TechniKrom®'s
process low-pressure (LPLC; 0 - 150 PSI) and medium-pressure
(MPLC; 0 - 300 PSI) liquid chromatography columns use true
dynamic axial compression. Axial piston compression allows
for high performance packing in minimal time. Placing constant
pressure on the piston gives it the dynamic capability of
maintaining a consistent bed in light of packing media shrinkage,
swelling, or channeling. This helps maintain an even long
lasting bed that gives the highest possible resolution and
sample distribution. Regulating this pressure controls the
piston pressure; even the most fragile resins can be packed
without crushing by setting the piston pressure as low as
3-4 PSI.
Return To Top
This unique distributor is an "active" design. Inlet
flow is directed through precisely machined horizontal channels
and vertically bored holes of precisely calculated diameters
to provide uniform distribution independent of frit or media
backpressure. It is incorporated into a low dead volume frit
assembly and provides minimal shear force, pressure drop and
band broadening.
The LPLC and MPLC columns are equipped with ports along the
side to aid in packing and unpacking. This design feature
was created with two ideas in mind: (1) to decrease the time
necessary to pack and unpack a column, and (2) to enable the
user to pack and unpack a column within a "closed"
system.
The leak detection quality assurance
system involves a uniquely designed port in the piston head
between the main piston seals; this system immediately signals
any compromise of the seals. If a seal is damaged, fluid will
flow into this port and out of the column through a separate
tube and fitting on the upper flange providing a visual alarm
before any product is introduced into the column. (It should
be noted that the only way to damage a seal is by improperly
removing or replacing the piston; a very rare occurrence.)
Return To Top
The two piston seals are composed of a FDA-approved UHMW-PE
or virgin Teflon. The bottom seal faces the stationary phase,
and the top seal faces air or hydraulic liquid (used to compress
the bed dynamically). The coefficients of friction (µf)
of these materials are very low and result in longer seal
lifetime. This material is much better than the elastomers
used in other column designs.
The end of the piston head (facing
the stationary phase) includes a liquid/scraper seal made
of FDA approved virgin Teflon or UHMW-PE. It performs as both
a liquid seal and a wall scraper to leave the column completely
clean during unpacking procedures, as evidenced by detailed
visual inspections.
Return To Top
Our frit design is that of "woven
mesh," with welded multi-layered 316L stainless steel
screens (polymeric or hastelloy versions are optional). As
a result, our frit/distributor plate assembly has a significantly
lower dead volume than the traditional sintered frit. The
high surface area and non-uniform pore structure of sintered
frits results in frequent clogging and higher back pressures.
The column design is the most compact
of any dynamic axial compression column on the market today.
Unlike other designs, columns up to 80 cm ID can be wheeled
through a standard doorway, and columns up to 1 meter long
can fit in a room with a ceiling height of just 8 feet.
TechniKrom's LPLC/MPLC columns are
designed for hoist free maintenance. Both of the column frits
can be removed, cleaned, and replaced without the use of an
overhead hoist or winch assembly.
Return To Top
5cm - 2m internal diameter (ID)
Up to 2 meter length
Custom designed and built to order
at our U.S. manufacturing facilities. Call 800-865-4100 (Int'l
847-467-4056) for details.
Lower cost adjustable bed static compression
and guard columns also available.
Pharmaceutical and biotech grade
only
• 316L stainless steel for all
parts of the column including legs, frames and internal parts
such as frits.
• Salt resistant passivated 316L stainless steel or Hastelloy
available.
• All seals made of FDA approved elastomers; eg., PTFE,
FEP, Viton.
• Sanitary design with minimized dead volumes and boroscopically
examined orbital piping welds.
For IQ/QQ submissions
All column parts are fully traceable
with individual PIN stamping and certificates of analysis.
Detailed operation manual includes all cut sheets for components
and column test reports (including ASME).
Fastest in the Industry
Fast delivery times and available inventory
enables us to meet your purification needs quickly and on
time.
Return To Top
• One year extendable warranty.
• Rapid response time for technical service and support.
|
